Clinical patterns of hypersensitivity to nonsteroidal anti-inflammatory drugs and their pathogenesis
Identifieur interne : 003948 ( Main/Exploration ); précédent : 003947; suivant : 003949Clinical patterns of hypersensitivity to nonsteroidal anti-inflammatory drugs and their pathogenesis
Auteurs : A. Szczeklik [Pologne] ; R. J. Gryglewski [Pologne] ; G. Czerniawska-Mysik [Pologne]Source :
- The Journal of Allergy and Clinical Immunology [ 0091-6749 ] ; 1977.
English descriptors
- Teeft :
- Adverse reactions, Allergy, Allergy clin, Aminophenazone, Analgesic, Anaphylactic shock, Angioedema, Aspirin, Aspirin intolerance, Asthma, Asthmatic, Asthmatic attacks, Biosynthesis, Blood pressure, Challenge tests, Chronic urticaria, Clin, Clinical immunology, Clinical patterns, Cutaneous reactions, Disodium cromoglycate, Dos, Erythematosus, Fenoprofen, Gryglewski, High doses, Histamine, Hypersensitive, Hypersensitive reactions, Hypersensitivity, Ibuprofen, Immunol, Indomethacin, Ingestion, Inhibitor, Intolerance, Lupus, Lupus erythematosus, Maculopopular rash, Mefenamic acid, Nonsteroidal, Nonsteroidal drugs, Noramidopyrine, Oral challenge, Oral challenge tests, Other hand, Paracetamol, Placebo, Polfa, Positive reaction, Positive reactions, Prostaglandin, Prostaglandin biosynthesis, Prostaglandin generation, Pyrazoline, Pyrazoline compounds, Pyrazoline drugs, Rhinitis, Synthetase, Synthetase inhibitors, Szczeklik, Untoward reactions, Urticaria.
Abstract
Abstract: Clinical observations coupled with challenge tests using 16 different nonsteroidal anti-inflammatory drugs were carried out in 123 patients with a history of allergy to analgesics. Several different patterns of hypersensitivity could be distinguished. Our clinical and experimental data suggest that in the largest group of patients studied the idiosyncrasy to aspirin-like drugs was not of immunologic type but was due to the suppression of prostaglandin generation in tissues of the patients. The adverse reactions to aspirin-like drugs were manifested as asthmatic attacks or urticaria/angioedema. In another group, the hypersensitivity was limited to pyrazoline drugs and was not related to inhibition of prostaglandin biosynthesis. This type of hypersensitivity, resulting in anaphylactic shock and urticaria, seems to have an immunologic background. In a patient with lupus erythematosus the hypersensitive reactions to analgesics were related neither to their chemical structure nor to their known biochemical activities. In a small group of patients the hypersensitivity to aspirin could possibly be attributed to the minute amounts of impurities present in some commercial products.
Url:
DOI: 10.1016/0091-6749(77)90106-3
Affiliations:
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Czerniawska-Mysik</name><affiliation wicri:level="1"><country xml:lang="fr">Pologne</country><wicri:regionArea>From the Department of Allergy and Clinical Immunology and the Department of Pharmacology, Copernicus Academy of Medicine Kraków</wicri:regionArea><wicri:noRegion>Copernicus Academy of Medicine Kraków</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">The Journal of Allergy and Clinical Immunology</title><title level="j" type="abbrev">YMAI</title><idno type="ISSN">0091-6749</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1977">1977</date><biblScope unit="volume">60</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="276">276</biblScope><biblScope unit="page" to="284">284</biblScope></imprint><idno type="ISSN">0091-6749</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0091-6749</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adverse reactions</term><term>Allergy</term><term>Allergy clin</term><term>Aminophenazone</term><term>Analgesic</term><term>Anaphylactic shock</term><term>Angioedema</term><term>Aspirin</term><term>Aspirin intolerance</term><term>Asthma</term><term>Asthmatic</term><term>Asthmatic attacks</term><term>Biosynthesis</term><term>Blood pressure</term><term>Challenge tests</term><term>Chronic urticaria</term><term>Clin</term><term>Clinical immunology</term><term>Clinical patterns</term><term>Cutaneous reactions</term><term>Disodium cromoglycate</term><term>Dos</term><term>Erythematosus</term><term>Fenoprofen</term><term>Gryglewski</term><term>High doses</term><term>Histamine</term><term>Hypersensitive</term><term>Hypersensitive reactions</term><term>Hypersensitivity</term><term>Ibuprofen</term><term>Immunol</term><term>Indomethacin</term><term>Ingestion</term><term>Inhibitor</term><term>Intolerance</term><term>Lupus</term><term>Lupus erythematosus</term><term>Maculopopular rash</term><term>Mefenamic acid</term><term>Nonsteroidal</term><term>Nonsteroidal drugs</term><term>Noramidopyrine</term><term>Oral challenge</term><term>Oral challenge tests</term><term>Other hand</term><term>Paracetamol</term><term>Placebo</term><term>Polfa</term><term>Positive reaction</term><term>Positive reactions</term><term>Prostaglandin</term><term>Prostaglandin biosynthesis</term><term>Prostaglandin generation</term><term>Pyrazoline</term><term>Pyrazoline compounds</term><term>Pyrazoline drugs</term><term>Rhinitis</term><term>Synthetase</term><term>Synthetase inhibitors</term><term>Szczeklik</term><term>Untoward reactions</term><term>Urticaria</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Clinical observations coupled with challenge tests using 16 different nonsteroidal anti-inflammatory drugs were carried out in 123 patients with a history of allergy to analgesics. Several different patterns of hypersensitivity could be distinguished. Our clinical and experimental data suggest that in the largest group of patients studied the idiosyncrasy to aspirin-like drugs was not of immunologic type but was due to the suppression of prostaglandin generation in tissues of the patients. The adverse reactions to aspirin-like drugs were manifested as asthmatic attacks or urticaria/angioedema. In another group, the hypersensitivity was limited to pyrazoline drugs and was not related to inhibition of prostaglandin biosynthesis. This type of hypersensitivity, resulting in anaphylactic shock and urticaria, seems to have an immunologic background. In a patient with lupus erythematosus the hypersensitive reactions to analgesics were related neither to their chemical structure nor to their known biochemical activities. In a small group of patients the hypersensitivity to aspirin could possibly be attributed to the minute amounts of impurities present in some commercial products.</div></front></TEI><affiliations><list><country><li>Pologne</li></country></list><tree><country name="Pologne"><noRegion><name sortKey="Szczeklik, A" sort="Szczeklik, A" uniqKey="Szczeklik A" first="A." last="Szczeklik">A. Szczeklik</name></noRegion><name sortKey="Czerniawska Mysik, G" sort="Czerniawska Mysik, G" uniqKey="Czerniawska Mysik G" first="G." last="Czerniawska-Mysik">G. Czerniawska-Mysik</name><name sortKey="Gryglewski, R J" sort="Gryglewski, R J" uniqKey="Gryglewski R" first="R. J." last="Gryglewski">R. J. Gryglewski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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